Its also important to keep in mind that Rhubarb has laxative action, which is desired in some cases but may cause discomfort in others. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. In this study design, neither an uterotrophic response nor a modulation of proliferation marker genes on mRNA level has been observed as response to the long-term application of the rhapontic extract. In most cases, rhubarb root side effects are associated with large dosages, especially those with longer durations. Importantly, this supplement didnt alter gynecological factors such as uterus health or bleeding [21]. 2015 Mar;12(1):61-9. Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. However, the study doesnt reveal crucial details such as sample size [54]. If your doctor suggests using rhubarb, work with them to find the optimal dosage according to your health condition and other factors. However, there are several claims that consuming rhubarb for a long time may result in bone loss, muscular weakness, irregular heart rhythm and potassiumloss. The product relies solely on one active ingredient. 2015 Dec;23(6):794-801. An official website of the United States government. Gut bacteria then break them down into active metabolites, which reduce the amount of water the colon reabsorbs. According to a meta-analysis of 16 clinical trials with over 900 people, rhubarb used with standard treatment is effective and safe for reducing pancreatic inflammation [25]. Rhubarb root contains lindleyin, a substance with estrogen-like properties. You can take it at any time of the day you choose. Scientific studies have confirmed numerous benefits that range from gut, liver and kidney protection to lowering inflammation and cholesterol. Results of double-blind, randomised, controlled clinical trials]. Clinical trials used doses ranging from 50 mg to 50 g/day, depending on the disease, type of extract, and other factors. Ji, S. M., Li, L. S., and Ji, D. X. The key ingredient in Estrovera is a phyto-estrogen from the Siberian rhubarb plant known as ERr 731, which has been shown to: Reduce the number and severity of hot flashes and night sweats about as effectively as low-dose estrogen. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. The clinical efficacy of external application of mirabilite and rhubarb combined with intrathoracic chemotherapy in treating malignant pleural effusion: A prospective, randomized, controlled clinical trial. Orgasms and great sex are still absolutely possible, through menopause and beyond. The information contained in this website is provided for general informational purposes only. Rhubarb stalk is commonly eaten in foods. 1996;16(11):649-651. Taking another Chinese herbal combination with rhubarb, Rheum E, helped slow the progression of chronic kidney failure in a clinical trial of 30 people. They can be eaten all summer long. 2009 Jan-Feb;15(1):24-34. [Clinical effect of Xinqingning combined low dose continuous gastrointestinal dialysis in treating uremia]. 2005;3(3):195-198. Fairbairn JW. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. [Nitrogen balance in uremic patients treated with rhubarb retention enema]. View abstract. View abstract. Your email address will not be published. It also reduced the need for anti-fever medication [1]. Rhapontic rhubarb is used for many of the same reasons as black cohosh, and it's the active ingredient in the popular . However, some prices do vary slightly. Would you like email updates of new search results? Therapeutic Research Faculty 2020. Below is a summary of up-to-date animal studies, cell-based research, or low-quality clinical trials which should spark further investigation. Rhubarb can grow oxalic acid stones. Postmenopause is the stage after menopause. 1980;90(8):718-724. In another study, Chinese rhubarb with Captopril also normalized levels of a marker of kidney dysfunction (IL-6) in the urine of people with chronic kidney failure [16]. The company states that you can save up to 20% if you order monthly shipments. Please enable it to take advantage of the complete set of features! These cause you to feel a sudden rush of warmth in your face and upper body. Zhonghua Yi.Xue.Za Zhi. In a clinical trial of 60 people with digestive tract bleeding and fever, taking ground Chinese rhubarb (3 g, 3-4x/day) with ground Chinese ginseng (sanchi powder) boosted recovery. Their perimenopausal treatment aims to regulate the menstrual cycle. 1996;21(6):364-6, 384. You are covered by the return policy of the third-party website where you buy the product, however, this manufacturer also has a return policy. At this point some women decide to go for hormone therapy[1], while others look for a more natural solution like a supplement. Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale. 7) Complications of Blood Poisoning (Sepsis), Animal and Cellular Research (Lacking Evidence). Federal government websites often end in .gov or .mil. Efficacy of Natural Formulation Containing Activated Charcoal, Calcium Sennosides, Peppermint Oil, Fennel Oil, Rhubarb Extract, and Purified Sulfur (Nucarb) in Relieving Constipation. You can also drag and drop the file into the provided field. Clipboard, Search History, and several other advanced features are temporarily unavailable. SelfDecode does not treat, diagnose or cure any conditions, It also reduced the length of the hospital stay and the need for IV fluids better than just antibiotics (Ceftizoxime sodium or Levofloxacin) [35]. In the US, you may report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. This capsule takes about 28 days to begin to be effective. Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. Such symptoms include: hot flashes weight gain low metabolism mood shifts night sweats difficulty concentrating The. Epub 2009 Oct 4. Observation of therapeutic effect in 50 cases of chronic renal failure treated with rhubarb and adjuvant drugs. Black cohosh side effects include: Stomach upset Rash Cramping Headaches Vaginal spotting or bleeding 2 Potential soy side effects include: J Tradit.Chin Med 1997;17(3):168-173. Tian, J., Chen, X. M., and Li, L. S. [Effects of Cordyceps sinensis, rhubarb and serum renotropin on tubular epithelial cell growth]. Disclosure of Material connection: Some of the links in the post above are "associate sales links." View abstract. In 92 people, Xiaozhang Tie, a Chinese herbal medication with rhubarb, moderately reduced abdominal swelling and overall symptoms. Safety and efficacy of NT, an herbal supplement, in treating human obesity. 2021;1308:309-352. doi: 10.1007/978-3-030-64872-5_22. Wang, Z., Wang, G., Xu, H., and Wang, P. [Anti-herpes virus action of ethanol-extract from the root and rhizome of Rheum officinale Baill.]. Rhubarb has some mild potential side effects like stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms. Taking rhubarb with other stimulant laxatives might cause more diarrhea and very low potassium levels. In case you hadnt noticed (fat chance! Systemic inflammatory response syndrome (SIRS) causes widespread inflammation. 2017;149(2):55-60. doi: 10.1016/j.medcli.2016.12.031. - 1 cup of green tea (make sure it's cool) - cup of blueberries (antioxidants) - 2 brazil nuts. Rhubarb has the potential to boost liver function, reduce fatty liver, and improve bile flow alongside conventional treatments. Jiao, D. H., Ma, Y. H., Chen, S. J., Liu, C. T., Shu, H. N., and Chu, C. M. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Zhong.Xi.Yi.Jie.He.Za Zhi. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. Note that each number in parentheses [1, 2, 3, etc.] Efficacy and safety of a special extract of Rheum rhaponticum (Err 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. This means if you can click on the link and purchase an item, we will receive a commission. View abstract. [Clinical study on niaodujing in treating chronic renal failure]. Chir Dent.Fr. Zhong.Xi.Yi.Jie.He.Xue.Bao. Some laxatives can cause diarrhea and decrease potassium levels. Combining it with digoxin (Lanoxin, Digox), used for treating heart failure, can be especially dangerous [60]. Epub 2013 Feb 13. Please see our Medical Disclaimer for more information. Women who have or have had breast cancer or uterine cancer. Rhubarb root and rhizome-based Chinese herbal prescriptions for acute ischemic stroke: a systematic review and meta-analysis. Greenway FL, Liu Z, Martin CK, et al. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. View abstract. In a clinical trial of 30 people, Chinese rhubarb (10 g/day, fed nasally 3x/day) added to the normal treatment improved gut function [31]. While it may be best known as an ingredient for pie, this vegetable is also used to treat constipation. Zhang, JH, Yao, XD, Song, Y, and et al. Jiao, D. H. [Clinical research on the hemostatic effect of rhubarb on peptic ulcer with acute bleeding]. WebMD does not provide medical advice, diagnosis or treatment. In addition to experiencing fewer hot flashes, women taking Siberian rhubarb extract can expect broad spectrum improvements in menopause symptoms, including better mood and better sleep. Long-term application of ERr 731 delivered no indication for any proliferation in the uterus. While the stalks can be used for cooking, the leaves are very poisonous. In a clinical trial of 45 women, Himalayan rhubarb (1,260 mg, 2x/day) was equally effective at reducing menstrual pain as the painkiller mefenamic acid [52]. The leaves of Rhubarb are toxic and should not be consumed. Bi, Z. Q. In women's health, these medicinal rhubarb species are speci cally used for the treatment of constipation in pregnant women.7,8 In all cases, the presence of emodin or rhein in these preparations may increase the risk of unwanted side effects in the breast and endome- Zhou, L., Hao, R., and Jiang, L. [Clinical study on retarding aging effect of tongbu recipe to traditional Chinese medicine]. The rhaponticin and desoxyrhaponticin mimic estrogen, and so theyre able to stimulate estrogen receptors. Rhubarb can be found in various forms, usually made from the roots and rhizomes of Chinese rhubarb [3, 4]: The below doses may not apply to you personally. The low quality of some studies is a potential drawback to the results [28]. *All individuals are unique. 2021;12(2):108-15. Pharmacology 1980;20 Suppl 1:128-130. Lu L, Li HQ, Fu DL, Zheng GQ, Fan JP. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [emailprotected]. 2021;51(8):916-925. They can also kill cancer cells and prevent metastasis by blocking excessive cell division [8, 9]. Diarrhea can increase the effects of warfarin and increase the risk of bleeding. 2007 Mar-Apr;14(2):270-83. You can BUY it directly from the Official Website. Select a condition to view a list of vitamins. View abstract. Zhong.Xi.Yi.Jie.He.Za Zhi. Analysis of 50 cases]. Evaluation of the efficacy and safety of Rheum rhaponticum root extract (ERr 731) for menopausal symptoms in perimenopausal Indian women: an interim analysis. Hence, the modulation of proliferation in the uterus was investigated by examining the effects on the mRNA expression of proliferation marker genes (Mki67, Pcna), on the estrogen-responsive gene C3 and on the estrogen receptors ER and ER. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(3):186-189. Soybeans and the products produced from them, such as tofu and miso, are a great source of phytoestrogens . One can suffer from stomach and intestinal pain, uterine contractions, and watery diarrhea. We additionally performed densitometry analysis of the proximal tibia metaphysis using peripheral computed tomography (pQCT) and quantified bone homeostasis markers in the serum to examine potential effects on the bone. On this basis, extracts of rhubarb have been tried for control of menopausal symptoms. 8600 Rockville Pike By activating this estrogen receptor, rhubarb extract has been studied and clinically demonstrated to . Rhapontic rhubarb root extract is the only active ingredient in this supplement. American College of Gastroenterology guideline: management of acute pancreatitis. Up to 83% reduction in hot flashes. Medicinal value of rhubarb Cooking rhubarb increases its polyphenol content and overall antioxidant capacity. I have a brand new unopened box of it and if you would like it text me at 412 265-5865 or email me at