Taking Baikal skullcap with these medications might decrease how well the medication works. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Scutellaria baicalensis Georgi extracts inhibit RANKL-induced osteoclast differentiation. 1998;61(5):27-29. Yune, T. Y., Lee, J. Y., Cui, C. M., Kim, H. C., and Oh, T. H. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. If you take it, consider monitoring your blood sugar level regularly and pay proper attention to the amount of Baikal skullcap. 12-10-2008;8(12):1652-1657. Successful treatment of pediatric psoriasis with Indigo naturalis composite ointment. J Ethnopharmacol. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. We currently have no information for BAIKAL SKULLCAP overview. Ong, E. S., Len, S. M., and Lee, A. C. Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry. View abstract. View abstract. [Pharmacological effects of flavonoids from Scutellaria baicalensis]. Studies on inhibitors of skin tumor promotion. Biochim.Biophys Acta 2011;1813(8):1465-1474. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. View abstract. View abstract. Gol'dberg VE, Ryzhakov VM, Matiash MG, et al. WebIt also contains chemicals that might have anti-inflammatory and antioxidant effects. View abstract. View abstract. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. Braude MR, Bassily R. Drug-induced liver injury secondary to Scutellaria baicalensis (Chinese skullcap). View abstract. View abstract. Blood 2-15-2008;111(4):2354-2363. View abstract. View abstract. Int Immunopharmacol 2014;23(2):558-67. Clin Pharmacol Ther 2007;83:471-6. Tong, R., Mehendale, S. R., Wang, C. Z., Shao, Z., and Yuan, C. S. Comparison of antioxidant effects of various Scutellaria baicalensis fractions and the potential role of catalase upregulation. View abstract. J Med Food 2009;12:1143-8. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Chan, E., Liu, X. X., Guo, D. J., Kwan, Y. W., Leung, G. P., Lee, S. M., and Chan, S. W. Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats. Br J Pharmacol 2009;157:1410-18. Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Journal of Dietary Supplements 2010;7:253. View abstract. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. Drug Metab Dispos 2005;33:537-46. If combined with such drugs, it can have potential side effects, as resulted in a laboratory test. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. FEBS Lett. Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. Neuroprotective effect of baicalein against MPTP neurotoxicity: Behavioral, biochemical and immunohistochemical profile. View abstract. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Scutellaria baicalensis is an herb used in traditional Chinese medicine to treat a variety of conditions including hepatitis, infections, and cancer. View abstract. 1995;15(8):465-467. Planta Med 2000;66:91-3. Chinese skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats. Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. Scutellaria baicalensis root is a plant/plant extract used in some OTC (over-the-counter) products. J Ethnopharmacol. Nat Prod Res 2008;22(16):1410-1412. View abstract. XI. Sasaki, K., Taura, F., Shoyama, Y., and Morimoto, S. Molecular characterization of a novel beta-glucuronidase from Scutellaria baicalensis georgi. J Agric Food Chem 12-3-2003;51(25):7276-7279. Wu X, Zhang H, Salmani JM, et al. View abstract. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. View abstract. Baicalein reduces airway injury in allergen and IL-13 induced airway inflammation. But there is not enough information to know if Baikal skullcap is the cause of these side effects. Eksp.Klin Farmakol. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. J Dermatol Sci 2007;46(1):31-40. View abstract. Nutr Res 2009;29:298-304. View abstract. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Wu, J. With cancer, where you get treated first matters. Pharmacol Biochem Behav 2009;92(4):642-648. Scutellaria barbata should not be confused with Scutellaria baicalensis. Baikal skullcap might increase how quickly the liver breaks down some medications. Apoptotic effects with the alkaloid scutebarbatine A occurs via cytochrome c and caspase-3/9 upregulation, and Bcl-2 downregulation(28). WebScutellaria baicalensis, a medicinal herb belonging to the Lamiaceae family, has been recorded in the Chinese, European, and British Pharmacopoeias. Visit the FDA MedWatch website or call 1-800-FDA-1088. Preclinical studies of S. barbata have focused mostly on colon, lung, and liver cancer models. 2007;42(10):1074-1077. Chou TC, Chang LP, Li CY, et al. Ren S, Cao D., Yang J, and et al. S. barbata possesses a range of antitumor activities via multiple intracellular targets(20), with major anticancer constituents identified as scutellarin, apigenin5-O--glucopyranoside, apigenin, p-coumaric acid, luteolin and 4-hydroxywogonin(22). Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. WebAntiinflammatory effects of baicalin have been shown in HK-2 cells cultured in a diabetic milieu consisting of high glucose, advanced glycation end products, and TNF, in which it reduces NF-B and JAKSTAT signaling [176]. Phytother.Res 2007;21(12):1187-1192. This Chinese herb may slow down blood clotting, increasing the risk of bleeding and bruising in people who already have some bleeding disorders. 2021 Jun 28;274:114052. Therefore, one should not take the herb on their own Rather; they should ask a doctor and go with a suitable preference for treating cancer. Surgery: Baikal skullcap might slow blood clotting. Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. Vopr.Onkol. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Sci 2008;99(4):689-695. Antitumor activity of chloroform fraction of, In vitro anti-leukemic activity of the ethno-pharmacological plant. It is also used as a diuretic, and should not be confused with Scutellaria baicalensis. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Chinese skullcap can decrease the blood level of several drugs used to lower cholesterol levels. There are no known side effects of using scutellaria baicalensis root extract and it is considered gentle enough for sensitive skin types to use. This study reports three major findings: (1) S. baicalensis has a potent inhibitory effect 2020 Apr;82(4):253-254. Thanks to its salicin content, willow bark is often touted as Scutellaria baicalensis root: Uses, [Effect of Radix scutellariae on the growth and form of Porphyromanus endodontics in vitro]. Leung, H. W., Yang, W. H., Lai, M. Y., Lin, C. J., and Lee, H. Z. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. Pharmacogenomics of human OATP transporters. Zhong.Yao Cai. 2010;16(2):32-40. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. View abstract. Toxicology 5-2-2009;259(1-2):10-17. This could change the effects and side effects of these medications. View abstract. View abstract. Food Chem Toxicol. Intern Med 2001;40:764-8. A., Attele, A. S., Zhang, L., and Yuan, C. S. Anti-HIV activity of medicinal herbs: usage and potential development. View abstract. At this time there is not enough scientific information to determine an appropriate range of doses for Baikal skullcap. Do you know this herb by any other name ? Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use Baikal skullcap. Jin BR, Chung KS, Kim HJ, An HJ. View abstract. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Users of this Web site should not rely on information provided on this Web site for their own health problems. Herbal hepatoxicity from Chinese skullcap: A case report. Int J Cancer 9-10-2003;106(4):559-565. Wu, J., Hu, D., and Wang, K. X. Wu, J. Y., Chung, K. T., Liu, Y. W., Lu, F. J., Tsai, R. S., Chen, C. H., and Chen, C. H. Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Skullcap should not be used during pregnancy or breastfeeding. Yin, F., Liu, J., Ji, X., Wang, Y., Zidichouski, J., and Zhang, J. Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells. 5-17-2011;135(2):359-368. J Cell Biochem 10-1-2010;111(2):274-283. Eksp Klin Farmakol 1997;60:49-51. Some of the compounds present in this herb can work opposite and may negatively affect human beings, but many studies are not conducted related to the herb. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. Keep in mind that natural products are not always necessarily safe and dosages can be important. Am J Chin Med 2009;37(3):621-623. WebScutellaria baicalensis Root Dry No Data Extract 100 4. View abstract. WebThe root of Scutellaria baicalensis is used as medicine. Guangxi Zhiwu 2008;28(3):373-378. Side effects are few and may include drowsiness. View abstract. May Help Fight Cancer Cells. View abstract. Facial eczema from a sunscreen: Scutellaria baicalensis, a novel allergen beginning to attract attention. But there isn't enough information to know if this is an important interaction. Talk with your healthcare provider before using Baikal skullcap if you are taking medications used for lowering cholesterol. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. View abstract. View abstract. View abstract. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. Toxicology 3-4-2009;257(1-2):80-85. View abstract. vitamins, herbs, dietary supplements a-z list. Kong XT, Fang HT, Jiang GQ, et al. 1997;52(11-12):817-823. View abstract. Morgan SL, Baggott JE, Morel, L, Desmond R, and Kendrach AC. Biomed.Chromatogr. View abstract. Your lithium dose might need to be changed. View abstract. Indian J Med Res 2008;127(6):610-615. Br J Pharmacol 2009;157:1410-18. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. You, C. L., Su, P. Q., and Zhou, X. X. Toxicol.Appl.Pharmacol 8-1-2011;254(3):221-228. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Breaks down some medications and it is considered gentle enough for sensitive skin types use. Studies of S. barbata have focused mostly on colon, lung, and liver models! 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