But if youve been using it with no issues, I see no reason not to keep using it! Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. I live on a farm that borders a forest, so coyotes/deer etc.. no avoiding ticks. That way if a tick does make it past the essential oil barrier and bite, itll die anyway. It treats both heart and intestinal parasites. (MDR1 -/-) following single oral administration at 5 times the . Honestly, I think K9 Advantix would beat Credelio as far as effectiveness, due to its repellent properties and ability to kill on contact. Theyre so fun and crazy at that age. As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. I would appreciate your comments on Advocate. Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. I went back and edited my comment for consistency. I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. I have been told that Advocate is safe for him at the recommended dose. For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. I found some good information on the Cyphenothrin in Parastar Plus in this article. Use These Products Infrequently, Only as Needed Thank you! This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. , Emily, thanks for a very helpful and informative article. However, heartworm preventatives are still safe for MDR1 drug-sensitive dogs to take at low, FDA-approved dosages. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. Thank you so much for writing this article!!! Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg Simparica 20 mg chewable tablets for dogs >5-10 kg . Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. But frankly we're baffled that they've approved it. This drug should be avoided in all dogs with the MDR1 mutation. Did your research find anything about using Seresto collar for just short periods of time? If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. (Of course, skin irritation can happen with any topical product.) ProHeart 12 is not effective against adult D. immitis. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. These medications are safe and effective for most dogs, and side effects tend to be mild. (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. Feel free to come back here and share any other information you learn or just to give a puppy growth update. I used Interceptor last year with no issues. Best of luck! At high doses, however, such as those used in treating parasites such as demodectic mange, ivermectin can cause neurologic effects in dogs with the MDR1 mutation. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. Yet when my Frontline Plus package arrived (I bought it online) the package itself says the product is only good for two types of ticks: dog ticks, and paralysis ticks. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. Yes, Simparica is a good flea treatment for dogs. If you think about it, come back here and let me and other readers know what worked best for you! From the standpoint of MDR1 dogs, it is safe. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. Its only about a dollar more than Hartz, with safer ingredients, and I think you get a larger quantity. Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. After her first heat she went into a false pregnancy. But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. Happy to help! For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. Under many circumstances, newer dog flea collars are safe options for flea and tick control (unlike older collars, which were largely ineffective). I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. I was unaware of MDR1 Mutation drug reactions at the time. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. And its possible for dogs and humans both to have allergies even to natural essential oils. Have you had any issues with Seresto? Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. Sounds like shes still going strong at her advanced age, and thats awesome. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. But of course, do talk to your vet and see what they know. Is credelio considered safe when using interceptor? I found it extremely helpful & educational. I recently saw the USA Today headline (I get notifications on my phone) about Seresto collars and made a mental note to read it later and update this article if need be then promptly forgot about it! What can I give my dog instead of Simparica Trio? She is just 1 year old. . Much appreciated! Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. Thanks. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. Im leaning toward Frontline Plus based on what you wrote. March 1, 2022 Learn what medications may be dangerous for your dog with the MDRI genetic mutation. The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. She was obviously in discomfort. Whether a dog reacts depends on the dosage of the drug. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. Fleas this summer in my part of CA are particularly bad. is it safe or not to use it? It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. Thanks Emily! The tail curling and pacing lasted over a week. What do you think about Frontline Gold? This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the information they need to make treatment decisions for each pet on an individual basis.. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. I follow this advice, since Im a safe-is-better-than-sorry person. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. This product should only be used in dogs and puppies over 8 weeks and who weigh more than 2.8 pounds. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. Scroll down to read their comments. THREE OF THE 8 FEMALES WENT INTO ESTRUS. Simparica Trio is fast-acting, starting to kill fleas and ticks within 4-12 hours. Dash is MDR1 mutant/normal. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Dec 26, 2017. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. You should still keep an eye on your pet when introducing new organic products. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. Second, Id like to ask a question if you dont mind. The manufacturer of ProHeart has tested the product for safety in dogs with the MDR1 mutation. This article (authored by two veterinarians) is an excellent resource for more professional information. If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. It can be used to destroy bedbugs, cockroaches, ants, and even fleas. So called vet and they said topically we should try Parastar Plus. Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. Based on my findings, Im not convinced of its superior safety. Wow! She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. Happy to help! Please help! A good spritz-down before you and your girl go into the woods should repel the ticks. Dogs with the mutation will react to those drugs. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! I think this is a couple years old. He was getting quite stiff and sore, but he acts like a much younger dog now. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? Thank you. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! Simparica starts killing fleas within 3 hours and ticks within 8 hours, and it keeps going strong for 35 days without losing effectiveness at the end of the month. Our dogs deserve the best. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. Once WSU has determined your dogs MDR1 status,board- certified veterinary pharmacologistDr. Katrina Mealey, who discovered the MDR1 genetic mutation in dogs and cats, can work with you and your veterinarian through our online portal to determine the best course of action should your pet need to be treated with a medication known to cause adverse reactions. Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. The rx I currently use on my dogs is serolaner (Simparica). Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. (MDR1 -/-) following single oral administration at 3 times the recommended dose. Hi Emily, . She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. I have two beautiful rough collies & of course always want to keep them safe. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. Please tell me if I am wrong. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. I have a 3 year old and an 11 week old Australian Shepherd. Nothing could be done for them. I have a unique situation. The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. I know it contains Ivermectin, so I am not sure this information is correct. Thank you for your article. Thank you for your article. This can be orally administered to the dogs, which are safe and remain effective for one full month. Hi, Thank you for this helpful article. Give Hollie Collie a good butt scratch or ear rub from me. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. (I have to give them baths with a very mild or medicated shampoo.) Dogs with the MDR1 mutation are not at increased risk for adverse effects. Simparica has not been evaluated in pregnant, breeding or lactating dogs. Im going to order some of the organic spray to help. (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) SIMPARICA TRIO is not effective against adult D. immitis. Where can I get them tested for MDR1 resistance. It has the same active ingredients as Seresto (plus one), so a bit stronger. This sensitivity is called flea allergy dermatitis. Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . 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